Having moxie means having enough cleverness, skill, creativity, fortitude and cajones
to solve (or, at least, to get out of) a difficult and personally threatening situation.
Originally a Yiddish
word, popularized by Moxie soda and the Kingdom of Loathing
. The caffienated soda tried to add 'vigor and energy' to the idea of moxie; and KoL invented the adjective (moxious
), and made 'moxie' also imply stylishness, accordion skills, and the ability to mix really good drinks.
(Having moxie doesn't always imply that you're the tricksy chutzpah
who caused this situation in the first place, but the terms aren't mutually exclusive either.)