It is two persons of the opposite sex who are always there for each other. They can not even be related but trust each other anyways as if they were 'brother and sister' These 2 persons can never lose faith in each other because they will need each other. In one way or another they will always love each other no matter what, and no one can separate them.
by Grid_Dzyr November 18, 2013
Get the sister and brother mug.While sitting on the floor changing my daughter's diaper, she's started flailing her legs around and kicked me in the 'brothers and sisters'.
by vankinney September 1, 2009
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sister and brother
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