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to fake someone out. To let someone think something, and when they discover the truth, you yell "PYSCHE!"
I thought we were going to Disneyland, this is just a PARK! PYSCHE!
by J to the E November 14, 2013
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To be excited or hyped for an event.
"Dude, I'm so Pysched for Coachella this year"
by Keith Urban is prettycool April 7, 2017
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Brain and body destroying narcotics disguised as medicine.
Pyschiatrist: here take these very safe non addictive pysch drugs for the rest of your life
Patient: OK as you say there safe, what's the harm

(a period of time later)

Patient: I feel terrible on these things and I can't stop
Pyschiatrist : I told you you'll have to take them for the rest of your life
Patient: fuck
by Peeko75 December 10, 2021
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