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1. (n.) The final incident which causes one or more parties to give up on attempting to remedy a situation.

2. (v.) Phrase that may be used in situations of extreme frustration or hopelessness in which one has reached the limit of one's tolerance for stupidity or other vexing qualities.
Dude! You totally just puked in the soup!!

Allison's fifth bout of syphilis was the puke in the soup, and she promptly gave up prostitution.
by Ben Thayer December 23, 2010
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