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The term "omgwthigo" is an acronym that stands for "Oh my gosh what the heck is going on?!" normally used when the person either truly is clueless on what is happening (usually wherever the other person is communicationg from) or as an expression while in a confusing online conversation, mostly with more than two people involved.

The longer version is more explicit, and self explanatory on what it is

"omfgwtfhifgo"
User 1 says: There is no way that this is happening
User 2 says: I know srsly this is mssd up
Used 3 says: Unbelievable
User 1 says: Yeah
User 4 says: omgwthigo
omgwthigo by Niteryder January 7, 2010
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omgwthitsp 

Oh My God What The Hell Is That Smell People
--

Comes after Osp (Ocassionaly Stink People) and GWP (Gag Worthy People)

Used in Ryan Higa's video "Rant on Stink People"
"omgwthitsp makes Ryan Higa die a little on the inside every time he smells them, he thinks their body smells like sour ass, salt and onion."
omgwthitsp by Tom Knudsen July 7, 2008

OMGWTFIROTFLMFAOWLQTMALOL 

The action of laughing so hard that multiple acronyms are necessary.

Stands for: Oh My God, What The F**k, I Roll On The Floor Laughing My F**king Ass Off While Laughing Quietly To Myself And Laughing Out Loud.
dumb person: Three plus four is eight.
smart nerd: OMGWTFIROTFLMFAOWLQTMALOL at your n00b math.

omgwthit?!?! 

omgwthit = oh my God what the hell is that?!?!
"In a haunted mansion

Guy 1 - Dude DID YOU HEAR THAT?!
Guy 2 - omgwthit?!?! (oh my god what the hell was that?!?!)
omgwthit?!?! by Arkthas October 10, 2007

OMGWTHITSP 

Oh
My
God
What
The
Hell
Is
That
Smell
People?!?!?!?
"DUDE OMGWTHITSP!"
OMGWTHITSP by asiandude17 July 27, 2009

OMGWTHISP 

an abbreviation for "oh my g*d what the hell is that smell people"

people that are so stinky that people tend to shout it in public
brygs: do you smell that?
michael: OMGWTHISP??
OMGWTHISP by michael isaac January 14, 2008