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The results after copious amounts of drugs have been consumed. You no longer have a grasp of reality and are acting high and crazy. Commonly used in relation to amphetamines, cocaine and similar
"I just had six lines of coke and a hit on that crackpipe, I am off my box mate."
He was slumped on the toilet, chewing his gums and drooling. Clearly he was off his box.

"You shit yourself in public? You must have been off your box."
by Tammy Eichhorst July 23, 2017
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