A grenade that hangs out with family members and is like a taxi take you ever where as long as you can give him gas money or food money
Guy1: Dude you see that man-mule.

Guy2: Yea, I bet those are his family members.

Guy1: Yea i bet they are ,look there giving him money!
by meanshi November 1, 2010
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Take a piss. Or do a Number 1. Especially if you a seriously full bladder. Not to be confused with see a man about a dog
<Early> I gotta see a man about a mule
<Brian> What?
<Early> Take a piss
- Kalifornia
by terminator March 10, 2004
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