1. The paradoxical state of being both a homosexual (homo) and a motherfucker (mofo). One who is both latently gay and depraved enough to have sex with his own mother.

2. A devoted male fan of rock group Good Charlotte.
"What a homofo!"

"I can't believe Dan could be such a homofo!"

"You goddamn homofo."
by Setkino September 21, 2007
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Girl 1: DAMN look at Will today! hes looking fineee
Girl 2: oh yeah hes a homofo
by Will the homofo November 11, 2010
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Homsexual and a mofo at the same time
You're one big homofo
by virushark October 15, 2003
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n. Person who is against homosexuality based on religious, social or personal beliefs, who actively opposes the achievement of equal rights of homosexuals. The homofoe may participate in political petitioning, sharing of anti-gay propaganda via social and electronic media, protesting, proselytizing/education, and voting to support unequal rights.
"I ain't afraid of homosexuals. I just don't want them marryin' or teachin' ma kids or livin' on ma block. Ain't no homophobe, more like a homofoe."

"During the second half of the 20th century homofoes proudly protested the advancement of the gay rights movement, but as social acceptance of homosexuality grew, homofoe activity dwindled."
by Miss Alaineous June 26, 2013
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combination between homo and mofo.... used to describe those that are being complete douche bags..
person 1-"OMG OMG OMG OMG GUESS WHATTT?!?!?"
person 2- what?
person 1- "UR MOM SAYS WHAT!!"
person 2- shut the FFFFFF....ront door, ur such a homofo...
by A&F model October 25, 2006
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