a ship between James Charles and Grayson Dolan, two people who are apart of the "sister squad" on youtube. They are obviously not dating and they have denied that rumor, but they are still super cute together.
Bob: Did you see the new sister squad video?
Rob: Yes! Grayson and James are so cute together.

Bob: Grames!
by avarose December 19, 2018
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A long faced human, typically in search of love abroad. A Grame will game your ass and take all your cash tax free.
Bro that girl you met on Tinder is currently living in Thailand, I think you matched with a Grame
by stinky nutz July 15, 2021
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The only thing that's preventing me from suicide.
Gramee: *Bothers me*
Me: *Whips out my 'Gramee-Be-Gone'*
Gramee: "oh crap"
by SyrupGods December 19, 2018
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