Abbreviated form of "Good luck with that shit." Usually said to someone trying to accomplish the impossible.
by woofrikinhaw May 16, 2007

by yreva11 February 20, 2009

by OrdealByFire47 June 30, 2008

by Khanada May 17, 2006

GLWTS often refers to "good luck with the sale" when used on comments on sale sites like auto auctions etc.
On an auction for a VW camper van:
Veddy nice – nothing matches the logic and layout of these and later Vanagon campers….GLWTS!
Veddy nice – nothing matches the logic and layout of these and later Vanagon campers….GLWTS!
by Tprov December 08, 2018

Acronym of "Good luck with that".
by Ten Ton Tigger November 05, 2013

by @modeOFdemus May 28, 2018
