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When playing a first person shooter, such as Call of Duty. One sneaks upon an unknowing victim, aims down sights through a scope at their anus/colon, and fires bullets relentlessly till the person dies.
"I was playing COD this afternoon when i snuck up on a newb and colonoscoped him."

"Aw man! that dude gave me a colonoscope"
by nolanoscopy October 29, 2014
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