That could be either of the two biggest digits on your feet;
or when spelled thusly: Big T.O.E. refers to the Big Theory Of Everything, which by it self, is self explanatory.

There is one on each foot.

The toe that has a nerve connected directly to a man's dick. Tug on this a little during fun reverse cowgirl and it creates an extra special sensation for him.

From the movie Stripes, it was used as a satirical compliment for Sgt Hulka who they just couldn't do without.

Someone who annoyingly goes overboard to get something done just to show up everyone, and then makes a total ass of himself, but won't admit it.

Someone who thinks he's in charge, while at the same time his "underlings" show outward support, but actually this person has no idea what he's doing and everyone else knows it.

Derived from the name 'Blackmore-Heal'; to have a large unlucky toe.

Someone who has an undeniably large big toe in comparison to the opposite toe, and other toes in the population of the world.

When a girl repeatedly moves her mouth up and down on the mans penis