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A pill of Sertraline Hydrochloride. Trademarked as Zoloft in the United States.

SSRI antidepressents.

Most commonly used by college students when they run out of Ecstasy.
Dude 1: I'm so depressed after that 3 day rager in the desert. I ate every last bit of molly I had.

Dude 2: That's wak yo. Got a Zofty?

Dude 1: Naw. It's cool though, I visited the campus doctor and told him of my ails. The medicine man hooked me up with a grip of Zofties. That should hold me until the kandi man rolls through.

Dude 2: The kandi man can.
Zofty by Chip Selekt August 19, 2012
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Zooty Call 

A zoom booty call

"A zoom booty call, a zooty call if that is not what it is called it needs to be but I believe it is." -Darkness Jackson (Stephen Jackson)

Bob: "Hey dude just had my first ever booty call on zoom. "
Steve: "You mean a zooty call? That is weak man."
Bob"Hey f*ck you @$$hole"
Bob: "Hey dud just had my first ever booty call on zoom."
Steve:"You mean a zooty call? That is weak man what were you doing touching your screen!"
Bob:"Hey f*ck you @$$hole"
Related Words
Zofty zooty zoftig Zafty zefty Zooty Call Zifty Zofey zofeya Zofeya carter
a term used in the song "big poppa" by biggie smalls, when he refers to getting zooty aka smoking the ganja
Yo man roll up that L i wanna get mad zooty
zooty by zooty June 26, 2007
Zofry is a nickname given to those who truly deserve it. It is such a good nickname that somebody would kill to get it, literally.
- Did you meet Zofry again?
- Yes, they are so good!
zofry by Zofry May 17, 2018

call of zooty

The feeling that rushes through your body when ones desires a "zoot" or "spliff"
Jamal: "im feeling a bit of call of zooty"
Kingston: "yeh me to i aint had a spliff in hours"
call of zooty by chicago joint October 1, 2008

zooty move 

when you are zooted and do stupid shit or act a fool
Yo Pete did a zooty move and fell on his ass when he tried getting out my car
Usually a hungarian street nigga, call somebody Zotya and you will die.
Zotya: "Hey Niki what's cracking?"
Zotya by Liptek November 11, 2019