To be perodically burned and dunked in one fatal swoop While it is vary rare to see a true "Volcano Burn", they are the most extreme and powerful form of humiliation.
Eric was dunked in the volcano and burn when he told his friend that he had a wet dream involving Casey Donovan.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.