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To be a constant or great annoyance to a single or a group of individuals.
That kid won't stop coming over and trying to talk to us.

I know he's such a tickle in the anus!

I hate when Joe sticks my borrowed pencil up his nose and then tries to return it to me.

I feel you bro, he's such a tickle in the anus.
by Alejandro December 07, 2014
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