It's a line from the 1987 film RoboCop. Spoken by an executive of a weapons manufacturer immediately following the death of his colleague at a failed demo of their new mechanized law enforcement robot. The character exemplifies the callous, dog-eat-dog mentality popular amongst business execs in the 80’s. It borders on sociopathic — similar to the nature in which Patrick Bateman speaks in American Psycho.
Cox: Too bad about Kinney, huh?
(Kinney shot to death by mech minutes ago)
Morton: *shrug* That's life in the big city.
by Proto Following Chomo January 23, 2021
What you say when you have lost your idealism and your find yourself as many people do: In a room drinking wine out of a burger king cup with ice in it, smoking a pack of Marlboro Reds a day and saying the N word.
Tim's Mother: "The cops are probably going to raid the house because they are running a pretty big coke operation upstairs."

Dennis: Life in the Big City

Tim's Mother: "Your kids who you haven't seen in five years called you. And because you were so drunk, they hung up the phone, and they never want to speak to you again."

Dennis: Life in the Big City

For further definition of the word visit

Tim Dillon's Podcast

Episode 164 Life In The Big City
by Party J Mac October 3, 2019