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A combination of STD and "Dino", a Spanish form of the name "Dean".

Used to insult, primarily, Americans named Dean by insinuating that they are dirty and have a sexually transmitted disease or other unsavory ailment.

Also customary is one person saying the letter "S" followed by the letter "T", and then a second person saying "DEANO" upon sight of the offending person named Dean.
"Hey, Frosty, do you know who's over there?"

"No, who?"

"STDEANO!"

Also:

(Dean walks into the room)
Person 1: S-T!
Person 2: DEANO!
by theoneandonlyman April 29, 2005
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