When there's simply too much mustache to handle. If you can't handle the 'stache then get out of Missouri; the mustache capital.
The other week I was chilling in Missouri and I kissed my girlfriend and she complained about my mustache being sufficiently prickly. She claimed it was mustache madness! She was then escorted out of the state because she couldn't handle it.
by Ozzy Fosburn January 14, 2012
A month long celebration of the mustache held in the month of march. Mustaches of all types are encouraged.
Guy:" Hey, what's with the mustache?"
Man:" It's March Mustache Madness dumbshit!"
by Charlie knows more than you November 6, 2008