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literally, "kill it!" It is usually an interjection. It comes from the Spanish verb, "matar", which means, "to kill." the lo is a direct object pronoun used for masculine objects. The pronoun "la" is used for feminine direct objects. You can also say "matale" which means not only kill him, but also her. Gender doesn't matter in that instance.
Un serpente, papi matalo
matalo by Martirio Graciela Ayala August 12, 2007
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What them niggas in Resident evil 4 say to each other to threaten Leon.
Villager:
Un forastero, Matalo”!
Related Words
Hawaiian for “thank you”. Also Hawaiian for “finger my hole-o 🤙🏽”.
Ladies in Hawaii be like “Mahalo!” the second I land. I mahalo-ed a girl last night…it was disgusting…she was well freaked out!
Mahalo by Hambone Fakenamington October 31, 2022

Mahalo Special 

An alcoholic concoction featuring a fifth of Taaka vodka and 2 sugar-free Red Bulls. First known origins found in Isla Vista.
“Hey Johnny, can I get a rip of that Mahalo Special?”
“Of fucking course dude! TEEHOO MAHALO!”
Mahalo Special by Jug Master March 23, 2021

La Mamalona 

A term Mexican-American son’s (takuaches) use to call their Dads or Parents truck.
Hey Cuhh let’s go out tonight, mi Apá me presto la mamalona.
La Mamalona by OMW2FYB916 October 16, 2019

Matabooboo 

Fake cocktail/drink. The word exists purely as a way of cracking a joke at a barperson's expense whilst your mates are standing round, thus guaranteeing you kudos for the rest of the evening.

For best effect, order a few normal drinks, then finish off by requesting a matabooboo.

The word originates from Yogi Bear's sidekick. See example for full usage and relevance details.
Donna: "Who's next?"
Wes: "Yeah, can I have 3 pints of Stella, two double vodka red bulls, a sex on the beach and a matabooboo".
Donna: "A what?"
Wes: "A matabooboo"
Donna: "What's a matabooboo"
Wes: "Nothing Yogi, what's the matter with you?"
Donna: "... knob."
Matabooboo by Mr. Positive July 24, 2008
A person who loves to have fun and is very indecisive. Usually being very beautiful, Mapalo's are very attractive and are picky when it comes to guys. They have two sides, the scary side and the nice side. People like Mapalo deserve to be treated right by the perfect guy and her smile is said to be a killer.She is loving and caring and that's what makes her an amazing girlfriend.
Mapalo by Kingsacè February 28, 2019