Top definition
Noun.

A female who conceives and births many children without the ability to pay for or properly care for the children. Typically lower-class women under the poverty line.

The term originated from a song by The Beatles of the same name.
That Octomom woman with the 8 kids is a real Lady Madonna.
by Mr. Tamborine Man October 18, 2010
Get the mug
Get a Lady Madonna mug for your fish Abdul.