Knuckle Cheese Share definition Flag The cheese that gathers on your knuckles when you're eating anything cheesy. "Damn, I can't go to the prom with all this knuckle cheese on me. Guess I'll have to lick it off. Waste not, want not says the lord." Knuckle Cheese by Viktor "Zero" Attica January 31, 2009 Get the Knuckle Cheese mug.