Once you have this you are fucked
She has you whipped
You can't leave her even if you want to
You are wrapped around her finger
George - What's up with Chase lately? He won't stop talking about Jessy.

David - He has Jessy Syndrome

George - How do you know?

David - Cause I had it...

George - Had?

David - HAVE OK. I WANT HER. I WILL DO ANYTHING FOR HER.
by John Mark Hose July 19, 2009
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A woman who has a phobia of dating men shorter than her.
Josh: Did you get her number?
Chester: Nah man, I am only 5'8", she's got Jessie Spano syndrome.
by Evilevad December 25, 2014
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