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According to my Spanish book, it means "Jeez!". It's more like a general expression of surprise, annoyance or exasperation.
"Hijole! Why did that puta even bother calling him?"
hijole by Lolita Alvarezz May 12, 2006
Damn did you see that hizley head?
Hizley by nestorp August 15, 2014

OFF DA HIZZLE 

Yo Dawg! That chick I met in da club last night was off da hizzle fa shizzle!! She could suck da chrome of a 57 Chevy! Yo, check it out ma negro, she's got a friend that she wants to hook up with you!! So later on tonight, we will be hittin skins! It's gonna be off da hizzle cuz!
OFF DA HIZZLE by DANTANA December 6, 2006
house, it rhymes with shizzle and nizzle.
Fo shizzle, get up out dis hizzle.
hizzle by Tweak November 29, 2002

foshizzle my nizzle in the hizzle 

I agree very very much my African American brother.
wanna go eat some fried chicken foshizzle my nizzle in the hizzle
Slang for “ his hole
Ohh hisole!
hisole by Useitwisely March 8, 2018