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hefferheffer 

The mastermind of organizing boss runs and selling boss items in the MMORPG Maplestory. He's known to be always dependable. Many people even let him go on their account. He's really THAT trustable because of his reputation.

He uses an epicly funded Dark Knight on Windia.
mapler#1: how did you get that Zakum Helmet?

mapler#2: hefferheffer did it while I was asleep

mapler#1: maan, why did I even ask...
hefferheffer by Babyboysamu July 11, 2009

Hefferweisengirl 

Usually a girl that is very fat brown and ugly and likes cheap beer like hefferweizen
Yo that girl is a hefferweisengirl
Hefferweisengirl by Swagrats October 5, 2016

Heffernan Syndrome 

A phenomenon common to TV sitcoms and commercials, but occasionally occuring in real life wherein an overweight or otherwise unattractive male seems to have obtained a mate of much greater attractivesness. The syndrome is named for the character "Doug Heffernan" from the TV series "King of Queens", but is also visible in other shows such as "Seinfeld" and "(most especially) "The Drew Carey Show".
Did you see that couple? It was a classic case of Heffernan Syndrome!

also acceptable:

That dude is such a Heffernan; she's too good for him!
An ancient clan of Vampires decended from Ireland. They can be incredibly beautiful and horrifyingly ugly.
"Dude did you hear about Billy?"

"Yea man, he totally got bit by a Heffern last night."
Heffern by Lamia{Disgrace} August 7, 2008

Heffernan's Syndrome 

AKA as Balanitis Swollen foreskin in the Orthopaedic surgery patient.
Wow!, Look at the Heffernan's Syndrome on that Ortho Patient!!!!! Holy F^#%in S*!T!!!!!!
Heffernan's Syndrome by JMCG2222 December 15, 2011

heffernan 

Boston folks that think they are better than everyone else.
oh you can tell he is a Heffernan
heffernan by TheSnitch April 16, 2011