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A word used used to describe someone extraordinarily difficult or contradictory. The type of person who will always have the opposite opinion of you and insist that they are right, even if they are quite obviously wrong and know that they are wrong, they disagree just to be annoying. Guisoyki is an accepted Scrabble word worth lots of points.
Niki: Is the sky blue?
Alison: Nope, why would you think that? You dummy.
Niki: Is your name Alison?
Alison: NOPE!
Niki: Wow you are totally a guisoyki.
Alison: Ouch, that hurts.
by CoolCats37825 January 02, 2012
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