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1. F.i.fu. (acronym) for Fatigue Induced Fuck-Up.

or
2. Fi.f.u. (acronym) for Fatigue Induced Foul-Up.

(censored version).

3. When one is so tired the easiest tasks are easily errored.

(Sometimes while the person doing the F.i.f.u is unaware

of it until after the fact).
1. (can be used as a verb.) I was so tired I Fi.fu.'ed, and

got off the bus at the wrong stop.

2. I was so tired I F.i.f.u'ed and, tripped going down the

stairs.

3. There was a complete F.i.f.u. on your T.P.S. report

Jonson, you obviously need some sleep.

4. Well todays' paper-work has been a total Fi.f.u.
F.i.f.u by Philly McWilly May 26, 2012
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D.G.I.F.U 

An acronym for 'Don't Get It Fucked Up' from the Chris Brown x Tyga album, 'Fan Of A Fan: The Album'. The song D.G.I.F.U also features Pusha T.
Guy 1: You need to stop fronting, you're finished here.
Guy 2: Stfu dude, I could buy this whole city if I wanted!
Guy 1: D.G.I.F.U, you don't have a stack of cash or a flashy pad, I saw you last week driving a taxi cab. Stop tryna make people thing you're loaded.
Guy 2: Uhm *walks away defeated*
D.G.I.F.U by ballinonem June 19, 2016

I.F.S.F.U. 

An acronym for "I Feel So Fucked Up". Can be used to refer to yourself in a emotionally or mentally draining state.
Texting:
'ngl ifsfu rn'
(I.F.S.F.U. can be combined with R.N., which is an acronym for "Right Now".)
I.F.S.F.U. by bigboigucci900 January 4, 2023

L.O.V.E.M.U.F.F.I.N.

The League Of Villainous Evildoers Maniacally United For Frightening Investments in Naughtiness (L.O.V.E.M.U.F.F.I.N.) is an organization dedicated to promoting evil.
L.O.V.E.M.U.F.F.I.N. is causing chaos again.
L.O.V.E.M.U.F.F.I.N. by MikefromAZ November 22, 2010

L.O.V.E. M.U.F.F.I.N.

Stands for the Leauge Of Villianous Evildoers Maniacally United For Frightening Investments In Naughtiness, a terrifying organization led by Dr. Doofensmirtz in the classic show, Phineas and Ferb.
"Man, did you watch P&F last night?"
"Yeah dude, I almost pissed my pants when I saw Dr. Doof and L.O.V.E. M.U.F.F.I.N. come on"
"Totally, the Leauge Of Villainous Evildoers Maniacally United For Frightening Investments in Naughtiness gets me every time"

L.O.V.E.M.U.F.F.I.N 

The League Of Villainous Evildoers Maniacally United For Frightening Investments In Naughtiness is an organization of evil scientists led by Dr. Aloyse Everheart Elizabeth Otto Wolfgang Hypatia Gunther Galen Gary Cooper von Rodenstein.
“Rodney’s gang, L.O.V.E.M.U.F.F.I.N almost destroyed the world over pretzels!

R.O.F.L.S.H.T.E.T.I.G.U.I.F.D.A.T.H.M.H.O.A.T.A. M.M.H.T.T.M.T.T.H.A.B.I.L 

rolling on the floor laughing so hard that every time i got up i fell down again then hit my head on a table and my mom
had to take me to the hospital all because i laughed.
The other day I was R.O.F.L.S.H.T.E.T.I.G.U.I.F.D.A.T.H.M.H.O.A.T.A. M.M.H.T.T.M.T.T.H.A.B.I.L ... it was kind of embarrassing.