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1.An annoying character.

2.One who always messes things up at vital times. A klutz.
3.Any video game character that is hard to kill, yet OHKO's you at any given moment.
4.Resident Evil 4 character which describes when a zealot is decapitated and the lizard looking plaga erects from its head.
Henry: "Did you invite Danny?"
Elijah: "No, he's a Dufraganez."

Leon: "Fuck! Another Dufraganez? Time for a flash grenade. What!? I don't have one? Fine, this mine thrower will do it."
by Ubercake August 07, 2011
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