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The phrase used to describe a group of women at work, who are pregnant at the same time. Up the duff is the colloquial term for being pregnant.

Duff Cluster can also be used as a collective noun.
Wow, we've got this amazing duff cluster at work at the moment. Kath and Simone have just had babies and Sandy, Michelle and Victoria are all pregnant.

Hey, check out the duff cluster over there.
by Yolanda Smartie October 04, 2009
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