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Don’t kill my vibe 

1) When someone asks you to not ruin their mood.

2) In simple terms it means to fuck right off.
Umm bitch don’t kill my vibe okay?!
Stop being stuck a buzz kill by killing my vibe!!

Don’t kill my vibe 

Used by females when having sex/masturbating and they want you to get them hornier
Don’t kill my vibe daddy

Bitch, don't kill my vibe 

Don't mess or interfere with their current emotional atmosphere and feelings. Popularized by a famous song by Kendrick Lamar.
*girl 1 is partying and drinking a day before a college test*
Girl 2: "Hey, we should get some sleep before the test, I know this is a good moment and all..."
Girl 1: "Bitch, don't kill my vibe!"