directile dysfunction 

A disability that causes those it afflicts to be unable to follow even the most simple instructions.

Bill: Dude, wtf!?! You were supposed to pick me up at the airport yesterday.

Tom: For realz? I thought that was tomorrow. My directile dysfunction must be acting up again.

directile dysfunction by Jtothebizzy January 23, 2010

Directile Dysfunction 

When your navigation system isn't working.

I wanted to go to Taco Bell, but my navigation to me to the post office. It must be having directile dysfunction.

Directile Dysfunction by LemonZest June 19, 2016

Deprectile dysfunction 

When you're too sad to jerk off, even though nutting would make you feel better

Guy 1: "I think I'm having Deprectile dysfunction"
Guy 2: "you need to see a therapist dude that stuff sucks to have"

Deprectile dysfunction by Epic989 September 2, 2019

[directile disfunction] 

one who has a great deal of trouble of with directions.

isabella: "where's the bubble tea place?"
lily: "2 blocks to the left, then 1 block up, and then 6 blocks east"
priscilla: "fool, it's right across the street!"
isabella: "dannng girl you got yo self a bad case of directile disfunction"

[directile disfunction] by lilllllly December 16, 2008