Despondos 

The state of being completely isolated from a situation place or time (often permanent)

Person 1: Hey why aren't you talking to Jeremy

Person 2: He messed up bad now he's in despondos

Person 1: Ohh good to know I'll steer clear

Despondos by Bread_Queen January 28, 2020

Despondex 

Made by Pfizer in collaboration with The Onion News Network, Despondex is the first drug designed to treat the symptoms of excessive perkiness. It can prevent loud joyful squeals when a friend calls, Christmas caroling, costume parties, talking in line at a grocery store, community potlucks, excessive hugging, and smiles.

Are you annoyingly happy?
Despondex could be right for you.
If you are in a good mood occasionally that is normal but if you have a persistant positive outlook on life you should ask your doctor about Despondex.
Now you too can waste a night sitting on the couch with your friends or family watching a TV show no one enjoys.
Despondex prevents happiness better than watching the news, considering man's impact on nature, checking your bank balance, and thinking about how old you are and how little you have accomplished.

Despondex by ericri September 10, 2009

Despondent 

down in the dumps

Fayaz is despondent when Anthony misses their 3:30 PM hug appointment. See also: inconsolable.

Despondent by BrandonWalsh April 11, 2014

Despoedespmnobes 

Good; being of good quality.

That was a despoedespmnobes piece of fish.

Despoedespmnobes by Mr. Rainbow Sunshine February 25, 2009

despondent 

Fucking hopeless.

Johnny was despondent because his IQ was 4.

despondent by Fred Jung. October 17, 2003

Despondent 

A state of depression. Unblissful.

despondent, distracted, your vicious, and romantic

Despondent by zZz_Jinxy_zZz January 15, 2007

DespondentMassAtrophy

The Industrail / Experimental / Grime / Noize band that will make your mind cave-in and your heart explode from your chest.

Members: Heir Boxen (insanity, programming, drum tracks, synth lines)

Influences:
-Terrorfakt
-Skinny Puppy
-Slayer
-Venetian Snares
-Aphex Twin
-Alcohol
-Automobile Accidents
-Violence
-Gunfire
-Very very bad things you dont like to think about

Sounds Like:
Everything that makes you sick,cry,or hurt inside...with a hammer
Despondentmassatrophy will pleasurably melt your mind.

Listen to DespondentMassAtrophy (D.M.A.), it will pleasurably melt your mind.

DespondentMassAtrophy by The Amorist June 2, 2008