Nickname for the sorority Chi Omega. Founded in 1895 at Arkansas University, Chi Omega is the largest women's fraternal organization in the world with over 300,000 initiates and 170 collegiate chapters. Chi O's are beautiful, classy, friendly, and fun.

Some famous Chi Omegas include Lucy Liu, Heather Locklear, Sela Ward, and Cybill Shepard.
(After winning some competition as Chi O usually does)
Bitter Ugly ADPi: What the hell?!?! You are all just a bunch of Chi Ho's!!
Chi O: Don't get mad...get better.

David Letterman: "Chi O's were ideal partners for all occasions. They were discrete, desirable, tactful, polite and fun. Every mom dreamed of her son coming home with a Chi Omega."

Open motto: Chi Omega - Having More Fun than you Since 1895
by Pike4Life June 14, 2006
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The easiest girls at Penn State University, subject of their own song.

(sung to the Disney tune Heigh Ho)

Chi O
Chi O
It's off to bed we go
With a little luck we'll all get fucked
Chi O
Chi O
Chi O
Chi O

I was so horny I was considering some recently paroled prison poonanie, but then I ran into a Chi O.
by John Lease March 3, 2004
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The nickname for the sorority Chi Omega. Chi O's are discrete, desirable, tactful, polite, and fun. They are always the classiest girls on every campus. All the guys want to be with a Chi O, and all the girls want to be a Chi O.
Tommy: who's that really cool hot girl?
Jimmy: that's a chi o, duh
by greekgirl April 7, 2005
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A bunch of cock sukin' girls that hang out together at college and think they are better than everyone else. Did i mention that they like suckin' cock.
I gave that chi o a philly fakeout, and her chi o buddy licked my cum off of her ear.
by Jocko Johnson March 15, 2004
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Whippets (nitrous oxide) and blow (cocaine) done in unison
Chi O Specials are the best drug combo ever
by Baseball_allstar1 April 7, 2017
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