A street filled with cookie cutter desert abodes in the suburbs of a southwestern city. Places like Phoenix and alberquerque are full of cacti sac neighborhoods.
No wonder you're a methhead Jesse, your house looks like your other seven hundred neighbors houses and the ocean is a thousand miles away. You could've made a middle class income in downtown alberquerque, but you didn't want to be like everybody else in your cacti sac neighborhood, well who does?
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.