When someone is being an ignorant scumbag and is acting like an annoying grump for no apparent reason.
Jake: Hey broskie, wanna head to the fair with me in a bit
Chris: No bro, piss the fuck off!
Jake: Jeez man, Who got your balls in a knot?
Chris: No bro, piss the fuck off!
Jake: Jeez man, Who got your balls in a knot?
by James Mcagee August 6, 2024

The instance when a females period blood clumps and drys in her pubic hair. "Its painful and gross."
"Fucking tracy, shes such a clot knot!" "I was late to work because i had to shower out my clot knots "
by pattytheinvisible September 30, 2014

by Bigchaddy July 25, 2022

by Glando March 15, 2021

She went to the crapper all bent over, like an hour ago, I bet she has a duce knot keeping her in there.
by Cooter polluter October 15, 2017

The muscular knot incurred during strenuous sex that requires the lover to stop and take a walk around the room.
by Trappergus June 5, 2021
