Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone
ARTHUR J. PRANGE JR. M.D.1, IAN C. WILSON M.B., D.P.M.2, ARCHIE M. RABON M.D.3, , and MORRIS A. LIPTON PH.D., M.D.1
1 Professors of psychiatry, University of North Carolina School of Medicine, Chapel Hill, N. C. 27514
2 Research psychiatrist, North Carolina Department of Mental Health
3 Resident in psychiatry, Dorothea Dix Hospital, Raleigh, N. C.
ARTHUR J. PRANGE JR. M.D.1, IAN C. WILSON M.B., D.P.M.2, ARCHIE M. RABON M.D.3, , and MORRIS A. LIPTON PH.D., M.D.1
1 Professors of psychiatry, University of North Carolina School of Medicine, Chapel Hill, N. C. 27514
2 Research psychiatrist, North Carolina Department of Mental Health
3 Resident in psychiatry, Dorothea Dix Hospital, Raleigh, N. C.
Twenty euthyroid patients with retarded depression were studied to determine the possible role of alterations in thyroid function in the etiology and treatment of depression. A battery of tests was administered regularly to measure change. Patients responded better to usual doses of imipramine when 25 µg. of L-triiodothyronine (T3) was administered daily. T3 was physiologically active, altering protein-bound iodine values and accelerating ankle reflex time. A possible explanation, based on relevant data from animal experiments, is that imipramine may elevate effective biogenic concentration, while T3 increases receptor sensitivity.
Loosing it has caused a huge EIAATH to the minds of many!
Loosing it has caused a huge EIAATH to the minds of many!
by KWlfDG88<*{{>UnDRWater January 19, 2010
Get the EIAATH mug.An Eias is a person who is allways getting rejected by women. You will constantly see him sucking on BBC. Most of the Eias poppulation was born at a 7-11.
Did you see Eias get rejected by Laura yesterday.
I fell so bad for him I wish he would be more like Chad
I fell so bad for him I wish he would be more like Chad
by Cooldog77022 January 24, 2019
Get the Eias mug.by Peppapepper May 30, 2020
Get the eiana mug.An Eias is a person who is allways getting rejected by women. You will constantly see him sucking on BBC. Most of the Eias poppulation was born at a 7-11.
Did you see Eias get rejected by Laura yesterday.
I fell so bad for him I wish he would be more like Chad
I fell so bad for him I wish he would be more like Chad
by Cooldog77022 January 24, 2019
Get the Eias mug.An Eias is a person who is allways getting rejected by women. You will constantly see him sucking on BBC. Most of the Eias poppulation was born at a 7-11.
Did you see Eias get rejected by Laura yesterday.
I fell so bad for him I wish he would be more like Chad
I fell so bad for him I wish he would be more like Chad
by Cooldog77022 January 24, 2019
Get the Eias mug.by God Himself69 October 25, 2017
Get the Eialin mug.by God Himself69 October 27, 2017
Get the eialin mug.