Down-syndrome Hammer Fiesta 

When an individual with Down-syndrome loses his/her shit, and proceeds to annihilate anything in reach with a hammer of some sort.

Did you see the news today?

Fuck the news.

Well Alabama was annihilated by a Down-syndrome Hammer Fiesta

Alright? Who gives a flying fuck about Alabama?

Down-syndrome Hammer Fiesta by Sodomy boy June 28, 2010

Post traumatic Down syndrome 

When some is saying some really dumb shit and you need them to shut up

Guy 1: bro what’s Obama’s last name?

Guy 2: you have post traumatic down syndrome if you don’t remember Obama’s last

Post traumatic Down syndrome by BONDEDFOOL April 22, 2020

Debbie Down Syndrome 

When somebody is acting liking a debbie downer, but is being retarded about it

Bill: Wow, the score is 12-11. It looks like its going to lose this game.
Matt: Wow, we're only down one point. You're being a real Debbie down syndrome

Debbie Down Syndrome by King Cunta August 12, 2017

ultra down syndrome deluxe 

When someone has 92 chromosomes.

Jeff:Takes ur shield potion in fortnite
You:Whats it like living with ultra down syndrome deluxe?
Jeff:It's alright, I get a lot of free stuff

ultra down syndrome deluxe by Bucket0011 May 16, 2018

Metastatic Down Syndrome

When someone is so stupid that a simple retard won’t do

Durning an operation. The attending surgeons asks the resident to pull on something so he can see. “Hey pull on that like you mean it”. The resident then pulls too hard and causes audible bleeding! Surgeon says “what is wrong with you? Do you have metastatic Down syndrome?”

Metastatic Down Syndrome by Silver dollar tranny October 28, 2020

Double Down Syndrome 

A temporary loss of judgment and higher reasoning capability that one may experience immediately after consumption of KFC's double-down sandwich. Initial symptoms may include confusion, euphoria, and slurred speech. These are soon followed by loss of physical coordination and language ability (several patients have been observed to repeatedly utter variations of the phrase "hurr herp derp"). Patients may then enter a trance-like state for prolonged, variable amounts of time. A full recovery is typical within a few hours to a few days, although in some cases lasting brain damage has been reported.

In the hospital, it was discovered that what psychiatrists initially believed to be severe mental retardation was nothing more than a case of Double Down Syndrome after a late lunch.

Double Down Syndrome by theloniius April 12, 2010

Down Syndrome 

A condition affecting a person on the basic genetic level in which one chromosome splits in three instead of two and causes heart defects, thyroid conditions, shorter extremities and slower brain development. Although, their brains are slower to develop, you won't find any of them judging so harshly that they will be sending ignorant definitions out for everyone to see. They will also never judge you for having no genetic reason to be as stupid as you so obviously represent yourself to be, as referenced by your definitions.

My niece has Down Syndrome and she is one of the joys of my life. She is not ugly in body nor in spirit. In fact, she loves unconditionally, so unlike those of us who take kindness for granted so much that we forget how to show it.

Down Syndrome by fed_up_with_ignorant_people August 15, 2005