An abbreviated term for the word "Mother Fucker".
First Example:

***Peter, Winston, and Edward all go down to the bar to talk about the 2020 Politics and all the shitshows and shitstorms that went down***

Peter: Guys?! Did you saw that 2020 U.S Election "Prayer" what jive-ass shit is that?!

Winston (sips drink): Heard of it, that mofo shit is crazy?!

Edward: IKR?!

All in Unison: What a jive-ass mofo year that year was!?!?!?!?

Second Example:
*** Takes place in an alternative contemporary 21st Century New York City Mafia***

The Don: This is some serious shitshow the little guys got themselves in.

Caporegime: Yes indeed, what mofo shit is this? Now our operations in Michigan and Illinois are now going to be crippled if they don't play ball.
by Peterson Conjurer May 5, 2021
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Person: “Did you know that hunter is the biggest mofo?”

Hunter: “Yes I am biggest mofo”
by Destini y’all December 2, 2020
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What to call your friends or an annoying person. Mofo, alternate meaning of Motherfucker
by thethickestofthemall July 16, 2021
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The person you see in the bathroom above the sink
Charlie: Hey, Marie do you know what an ugly mofo is?
Marie: Of course I do! Just look in the bathroom above the sink and you'll see one
Charlie: God damnit
by Shady~Rose~06 March 25, 2021
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