down river syndrome

When a person has chromosomal damage from living down river near Detroit

Man that guy has a bad case of down river syndrome

by Kauai-kimo September 23, 2022

Down syndromic

Just another way to call someone with Down syndrome

Look at that retard he’s so down syndromic

by Sellout President September 5, 2023

Phantom Down Syndrome

When somebody doesn’t have Down Syndrome but they look like they should

Bella Ramsey and Halle Bailey have Phantom Down Syndrome

by Sexier Boomhauer April 24, 2025

Deployment Driven Down Syndrome

A neurological disorder generally presenting itself in males aged 18-40 as a result of deploying to environments that are so hot the brain cooks inside of a helmet that is bombarded by high frequency radio waves and X-ray radiation while simultaneously trying to figure out exactly what the mission is. The people who are handicapped by this syndrome return noticably impaired in both mental and physical capabilities.

My uncle has Deployment Driven Down Syndrome (DDDS). He spent 9 months looking at the same patch of desert for 8 hours a day during OSS while running a backscatter.

by The Cap N' August 21, 2023

Pick-up-till-put-down Syndrome

A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.

Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.

by NinjaSlayer_936 January 1, 2021

Dicked Down Syndrome

Temperamental shift in females caused by increased testosterone levels stemming from big dick driven polyamory and excessive sexual intercourse. Leads to a reduced ability to pair-bond and leads to a shift in sexual selection choices (from "preference seeking" to agreeableness and stability). Tell me that I'm fucking wrong though shit-brains.

Iam "Did we do one on Dicked Down Syndrome already?"

Hym "Hmm? No... I don't think so..."

Iam "Then how did predictive text know that 'ability to' would be followed by 'pair-bond'?"

Hym "Hahaha! Even the predictive text knows it's true!"

Iam "We must have used that line before..."

Hym "I'm surprised we haven't used 'big dick driven polyamory' until now. Seems like we've been sitting on that on for a while. Just like the $10 and hour whore! Bah dum tss! HAHAHAHAHAAAA!!"

Iam "I'm serious though. If only 3% of the population have 'dark triad traits' and we don't know why women are attracted to them; how for you account for the other 7-17% of men who are hyper-attractive to women?"

Hym "You account for it with big fat cocks. They're attracted to 'dtt' because sometimes people with 'dtt' have fat meaty dongers and your daughter loves it. Hahahaha!!!"

Iam "I mean isn't it strange that he never asks what the commonality is between the hyper-successful men with 'dtt' and those without?"

Hym "Remember how she started crying when we called her a $10 whore to her face? HAAAHAHAHAHAHAHAHAAAA!!!"

by Hym Iam April 13, 2022

Yes in a down syndrome voice

When someone says yes but like they are missing chromosomes

"YEEEEEESSSSSSS"
"oh no hes doing yes in a down syndrome voice"

by WildWillez December 13, 2020