the incredible sinking feeling leading up to and devastating depression following the finale of the hit TV show LOST, leaving you fulfilled knowing it's over, yet so very empty, because, well, it's over.
Person 1: I'm kind of concerned about Adam today...do you know what's wrong?
Person 2: Do YOU know that LOST ended last night so that's why he's locked himself in his room, turned off the lights, and continues to say the numbers as he cries himself to sleep?
Person 3: Oh yeah, my doctor warned me about post-LOSTdom depression... I told him not to worry because I watch Grey's Anatomy and that makes me cry all the time. So then I said he should probably worry about that...
Person 1: You should probably not ask Janell to do much today. Or Kim. Or Shawna. Or Andy. Or. Terry. Or any LOST fan for that matter. They're suffering from post-LOSTdom depression.
Person 2: Maybe they could just start watching House...?
Person 1: Shut your face. You really don't get it. They practically lived on that island.
Person 2: Do YOU know that LOST ended last night so that's why he's locked himself in his room, turned off the lights, and continues to say the numbers as he cries himself to sleep?
Person 3: Oh yeah, my doctor warned me about post-LOSTdom depression... I told him not to worry because I watch Grey's Anatomy and that makes me cry all the time. So then I said he should probably worry about that...
Person 1: You should probably not ask Janell to do much today. Or Kim. Or Shawna. Or Andy. Or. Terry. Or any LOST fan for that matter. They're suffering from post-LOSTdom depression.
Person 2: Maybe they could just start watching House...?
Person 1: Shut your face. You really don't get it. They practically lived on that island.
by VreeSquibcakes May 23, 2010
Get the post-LOSTdom depressionmug. The all consuming pain that takes over your life when you return home after traveling for a long period of time. The feeling that something is missing or something is wrong. It is a devastating, depressing fase in your life, that will very likely be one of the hardest things you have to go through.
The feeling of not belonging and always missing little pieces of your heart is something you have to learn to live with.
The feeling of not belonging and always missing little pieces of your heart is something you have to learn to live with.
P1 "my life doesn't make any sense, I don't feel comfortable in my own home"
P2 "wow, that sounds horrible"
P1 "yeah, I'm having a post-traveling depression"
P2 "wow, that sounds horrible"
P1 "yeah, I'm having a post-traveling depression"
by LeonoraChristina January 16, 2016
Get the post-traveling depressionmug. Coming out of quarantine with BIG loneliness vibes like you’re reminiscing for all the times u been out w your ppl, but OH, that was several boyfriends ago.
Lauren got post quartum depression BAD. Only friends she got left are the teenagers she play Fortnite with AND now they ghosting her too! Must be why she b posting photos of kids that ain’t his on fb.
by Vicki Veritas May 24, 2021
Get the post quartum depressionmug. 
When you miss going to universal with your friend and you look at all the good times you had and you realize how much you life sucks, yeet. Also you remember all the jokes and you realize how you should have done more, so much regret. SMH
by Heyyeets December 10, 2018
Get the post universal depressionmug. Condition experienced when an individual becomes slightly depressed and generally stagnant as a result of a recent departure from Disney
by ScarlettHolmes July 14, 2016
Get the Post-Disney Depressionmug. When something that you have put a lot of time into recently is finally over (like the finale to a tv series that you love, or the end of a great video game trilogy) you are sometimes left melancholy, and with a feeling of "what do I do now". This lingering sadness is called "Post Completion Depression", though it's often shortened to P.C.D.
Anime enthusiast: So have you finished watching Kill la Kill yet!?
Casual anime fan: Yeah, it was great, in fact, I think I'm starting to get Post Completion Depression.
Casual anime fan: Yeah, it was great, in fact, I think I'm starting to get Post Completion Depression.
by LILJJH September 11, 2015
Get the Post Completion Depressionmug.