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Three-Nil Down Syndrome 

The sudden onset of fucktardery amongst your FIFA team when you go three-nil down.

Symptoms include: The inability to pass to anyone, inability to tackle, sudden urges to set up the opposition for sitters and in bad cases, the complete loss of the ability to retain possession.
"How have you just scored with Stuart Downing?"

"You were 3-0 down, mate. There's no way your defenders could tackle a player of Stuart Downing's capability once Three-Nil Down Syndrome had kicked in".

Mexican Down Syndrome 

A semi-uncommon disorder among Mexican immigrants, MDS consists of a total lack of knowledge of American culture and language. Phrases such as "Come over, i'll cook you", "I love the smell of burn", "Can I use powerful words?", and "Smelt" are used frequently. Patients diagnosed normally don't have many friends, and are give shit by nearly everyone.
Jay: Did Rosa just say,"Shit my hole"?

Matt: Give her a break, her doctor says she has a case of chronic Mexican Down Syndrome.

Georgia down syndrome

She is the most annoying person and gay and weird and annoying and gay person u will meet. no offence or anthing but she is gay
Georgia down syndrome: im annoying
Toby: I know
Georgia down syndrome: im gay

Freddy Down syndrome 

Freddy Down syndrome -

A name for a boy name quinton who’s bitmoji looks like Freddy Kreuger . And he bullies gram for being named after a cracker when he’s a Down syndrome nacho taco chimmy chonga.
look it’s Freddy Down syndrome ! He prollys Down syndrome

Post Traumatic Down Syndrome 

Kind of like a brain fart, but much more severe. This usually happens in a discord call with your closest friends because of course it does.
Friend: Have you seen Mike anywhere?

You: No I haven't seen hyimom.

Friend: Hyimom?

You: Oh my god I have Post traumatic Down Syndrome

Phoenix Down syndrome

It means you are overly obsessed with the game series known as "FINAL FANTASY." It also means you have no life whatsoever, because of your obsession. Phoenix Down is a type of item in the game that lets you revive one character in your group.
"Dude, look at that loser, he's got a bad case of Phoenix down syndrome."