mystruzzle Share definition Flag a puzzle bought at a thrift store that is missing an unknown number of pieces thus being a mystery as to how to put the puzzle together. I bought a mystruzzle from Goodwill the other day and it was difficult to put together. mystruzzle by T. Rog March 10, 2010 0 0 Get merch Get the mystruzzle mug. Buy Now — $32.95 See more merch