Buffiest Share definition Flag Pronounced buff-e-ist, used to describe when you’re best buddies with someone but it is not a good enough word. -“Hey! Are you and that guy best buddies?” -“No, we’re actually best buffiests.” Buffiest by coolleanbeans25 July 18, 2018 0 0 Get merch Get the Buffiest mug. Buy Now — $32.95 See more merch