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JPII is an acronym for Blessed John Paul the second. Used by the youth of the Roman Catholic Church, it is an easier way to say his name.
Hey, did you hear? JPII was beatified!
JPII by ITisJUSTme July 19, 2012
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JPII High School 

A co-ed private high school in Plano, TX. It's amazing! The girls are hot and the guys are cool. Partying like no other. Known as a pharmacy. Not true.
JPII High School by Ryan O Connel October 16, 2008