Southern Discomfort 

A euphemism for diarrhea, aka the hershey squirts. The term is a play on Southern Comfort, an alcoholic drink and the modified version refers to discomfort in the southern region of the body, the bowels.

Mike - "Are you feeling any better, Elizabeth?"
Elizabeth - "No, I've still got some Southern Discomfort..."

Southern Discomfort by LizardBreath16 August 10, 2009

Entering the discomfort zone 

To intentionally do uncomfortable things

"What are you doing?"
"Im (Entering the discomfort zone)"

Entering the discomfort zone by NonSkrapple April 18, 2022

proctological discomfort

royal pain in the ass.

With her constant moaning, Thelma was fast becoming a proctological discomfort.

proctological discomfort by the real pappapittmudman April 23, 2006

Culinary Discomfort 

The feeling you get when someone near you is eating a gross combination of food and/or sauces.

Person 1: Do you see that kid over there? What is he eating?

Person 2: Oh that's Person 3, he eats the grossest combinations of food I've ever seen. Looks like today he brought a ham sandwich with ranch dressing and bar-b-que sauce and he's dipping it in his milk and his soup. Gross.

Person 1: That causes me to have a lot of Culinary Discomfort. I wish he would just stop.

Culinary Discomfort by Can't stand that smell guys January 2, 2013

Thumb Of Discomfort

when you yell out "THUMB OF DISCOMFORT" and swiftly lodge your thumb deep within another persons asshole and you suprise the hell out of them. If you miss and hit the cheek the person might thing your gay and not ghey

me: *sneaks up on someone* THUMB OF DISCOMFORT!
someone: huh??
me: *SHOVES*
someon: OMFG!

Thumb Of Discomfort by onge October 31, 2004

Social Discomfort 

To feel uncomfortable around people attached to you

Bryce felt so much social discomfort with juli around him

Social Discomfort by Xrusii April 7, 2022

Disuncomfortable 

When something is so cringy and inappropriate that that you reach another level of discomfort.

Did you see that guys haircut? It made me disuncomfortable. AA

Disuncomfortable by aro998 February 5, 2018