Deffo Jeffo Share definition Flag It means Definitely. Deffo is short hand for Definitely, just add a Jeffo for coolness! Q 'You want to go to the movies?' A 'Deffo Jeffo!' Deffo Jeffo by rachcook182 March 21, 2007 0 0 Get merch Get the Deffo Jeffo mug. Buy Now — $32.95 See more merch