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a few tacos short of a combo platter 

someone who is mentally not with it...looney, lacking intelligence or just plain crazy.
yeah, you could say Jane was not the brightest bulb in the box, her elevator didn't go to the top floor, she is a few tacos short of a combo platter.

two tacos short of a combo platter 

"Man.. that guy's two tacos short of a combo platter!"