ibuprofanity Share definition Flag A verbal ibuprofen of sorts by using cleaner words to replace vulgar or profane words in order to cause the listener less "pain". Holy shyte? Stop with the ibuprofanity. There's no kids here. Just say "holy shit". ibuprofanity by AmadeuS469 June 27, 2018 0 0 Get merch Get the ibuprofanity mug. Buy Now — $32.95 See more merch