1 definition by lightjak2210

1) Saying that you have the situation in the palm of your hand.
2) When something happens that causes you to give up.
I'm going to the movies in my new APC's and a white v-neck. It's game over duude.

I was talking to this girl and I found out she has a boyfriend. It's game over.
by lightjak2210 September 3, 2010
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