a "Yoko Ono" must be understood in the context of a music band/group. A "Yoko Ono" makes reference to former wife of late Beatles member, John Lennon. A "Yoko Ono" is a girl that holds a relationship with a member of a band and eventually breaks up the band. This is due to a high level of bitchiness on the girl's behalf and a the male band member being clingy and or whipped.
Yoko Ono has his dick on a leash.
That Yoko Ono is gonna destroy the band.
You Yoko Ono, you're tearing the band apart!