1 definition by Trevor3657
a "pandemic" that is used by boys as an exuse to hold a girl's hand. Very effective. The only known cure is to hold the girls hand and apply pressure. You must also give the girl a hug after letting go of her hand.
Linus: OMG!!!
Taylor: What?
Linus: You have Knuckleitis!
Taylor: oh no!
Linus: Ill save you! now give me your hand.
Taylor: What?
Linus: You have Knuckleitis!
Taylor: oh no!
Linus: Ill save you! now give me your hand.
by Trevor3657 February 12, 2009